Pyridobenzodiazepines: a novel class of orally active, vasopressin V 2 receptor selective agonists

…, TJ Caggiano, DK Williams, EJ Trybulski, X Ning…

文献索引：Failli, Amedeo A.; Shumsky, Jay S.; Steffan, Robert J.; Caggiano, Thomas J.; Williams, David K.; Trybulski, Eugene J.; Ning, Xiaoping; Lock, Yeungwai; Tanikella, Tarak; Hartmann, David; Chan, Peter S.; Park Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 954 - 959

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被引用次数: 32

摘要

Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY- 151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V2 receptor selective agonists exemplified by the 5, 11-dihydro-pyrido [2, 3-b][1, 5] benzodiazepine as ...