Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors

…, Y Uesugi, H Kim, J Yoshida

文献索引：Nagaki, Aiichiro; Uesugi, Yuki; Kim, Heejin; Yoshida, Jun-Ichi Chemistry - An Asian Journal, 2013 , vol. 8, # 4 p. 705 - 708

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被引用次数: 21

摘要

The development of mild and selective methods for introduction of fluorine atoms into organic molecules is an important objective because this element exerts unique influences upon physical, chemical, and biological properties.[1] In fact, fluorinated aromatic groups enhance solubility, bioavailability, and metabolic stability compared with nonfluorinated analogues. Especially, functionalized aryl fluorides have a vast array of biological ...