Bioorganic & medicinal chemistry letters

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

IR Baxendale, SV Ley

文献索引：Baxendale, Ian R.; Ley, Steven V. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1983 - 1986

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被引用次数: 106

摘要

Sildenafil 1 (Viagra™), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods.