Tetrahedron

Total synthesis, enzyme-substrate interactions and herbicidal activity of plumbemicin A and B (N-1409)

IA Natchev

文献索引：Natchev Tetrahedron, 1988 , vol. 44, # 5 p. 1511 - 1522

被引用次数: 27

摘要

The unusual natural amino acid 3, 4-didehydro-5-phosphono-D-norvaline, D4, and the cyclic analogue 14 have been synthesized by four-and three-component condensation of the aldehydes 3 and 10, respectively. Strict selectivity has been observed in the enzyme- substrate interactions with the enzymes phosphodiesterase I, alkaline phosphatase, α- chymotrypsin, urease, and alkaline mesintericopeptidase. The tripeptide antibiotics ...