Design, synthesis, and molecular modeling of novel pyrido [2, 3-d] pyrimidine analogues as antifolates; application of Buchwald–Hartwig aminations of heterocycles
A Gangjee, OA Namjoshi, S Raghavan…
文献索引：Gangjee, Aleem; Namjoshi, Ojas A.; Raghavan, Sudhir; Queener, Sherry F.; Kisliuk, Roy L.; Cody, Vivian Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4422 - 4441
Opportunistic infections caused by Pneumocystis jirovecii (P. jirovecii, pj), Toxoplasma gondii (T. gondii, tg), and Mycobacterium avium (M. avium, ma) are the principal causes of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). The absence of any animal models for human Pneumocystis jirovecii pneumonia and the lack of crystal structures of pj DHFR and tg DHFR make the design of inhibitors challenging. A ...
