Design, synthesis, and biological evaluation of (e)-3, 4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents

…, R Zhu, C Cheng, Y Du, Z Ma, Z Zhang…

文献索引：Ning, Xianling; Guo, Ying; Wang, Xiaowei; Ma, Xiaoyan; Tian, Chao; Shi, Xueqi; Zhu, Renzong; Cheng, Can; Du, Yansheng; Ma, Zhizhong; Zhang, Zhili; Liu, Junyi Journal of Medicinal Chemistry, 2014 , vol. 57, # 10 p. 4302 - 4312

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被引用次数: 15

摘要

Novel (E)-3, 4-dihydroxystyryl aralkyl sulfones and sulfoxides were designed and synthesized as new analogues of 1, which showed interesting multifunctional neuroprotective effects, including antioxidative and antineuroinflammatory properties. Specifically, target compounds display excellent potency in scavenging reactive free radicals and demonstrate potent effects against various kinds of toxicities, including H2O2, ...