Journal of Medicinal Chemistry

Synthesis of potential anticancer agents. VIII. Benzaldehyde mustard derivatives and related compounds

FD Popp

文献索引：Popp,F.D. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 627 - 629

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被引用次数: 10

摘要

The previously reported hydrazide I (R=-CHSCN, R'= H) 5 had some activity and hence several other hydrazides of the type I have been prepared. These were at best only slightly active against the Dunning leukemia in rats when administered in doses of up to 500 mg./kg. to an established tumor on day seven.'In view of the activity of several of our Schiff bases (11), 486 hydrazones (111) were prepared in order to determine the effect on activity of an ...