A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.
![ethyl 2,3,4,5-tetrafluoro-α-[[[1-(hydroxymethyl)cyclopropyl]amino]methylene]-β-oxobenzenepropanoate结构式](https://image.chemsrc.com/caspic/456/114636-48-5.png)
![ethyl 9',10'-difluoro-7'-oxospiro[cyclopropane-1,3'(2'H)-[7H]pyrido[1,2,3-de][1,4]benzoxazine]-6'-carboxylate结构式](https://image.chemsrc.com/caspic/318/113211-51-1.png)