Chemische Berichte

Amination, III. Trimethylsilanol as Leaving Group, V. Silylation—Amination of Hydroxy N??Heterocycles

H Vorbrüggen, K Krolikiewicz

文献索引：Vorbrueggen, Helmut; Krolikiewicz, Konrad Chemische Berichte, 1984 , vol. 117, # 4 p. 1523 - 1541

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被引用次数: 42

摘要

Abstract Hydroxy N-heterocycles such as 18, 21, 26, and others are efficiently aminated in a one-step/one-pot procedure by silylation-amination to give 20, 23–25 etc. Silylation converts aromatic hydroxy N-heterocycles into activated and lipophilic intermediates of type 3, 8 which react in situ with ammonia, primary or secondary amines to form the corresponding mono-, bis-or tris-aminated products (5, 10). This addition-elimination of amines to O- ...