Chemistry–A European Journal

Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)/cyclization cascade sequence as the key step

J Li, N Wang, C Li, X Jia

文献索引：Li, Jian; Wang, Ning; Li, Chunju; Jia, Xueshun Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9645 - 9650

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被引用次数: 2

摘要

Abstract Multicomponent cycloadditions with readily available isocyanides, allenoates, and isatylidene malononitriles are disclosed. This reaction, which does not require the aid of any catalyst, allows the efficient syntheses of spirocyclic oxindoles with excellent regioselectivity. Reactions with ethyl 2, 3-butadienoate and various structurally diverse α-and γ-substituted allenoates are also fully explored. Remarkably, we have shown that the usual three- ...