Role of substrate reactivity in the Glutathione Peroxidase (GPx) activity of Selenocystine
…, F Kumakura, M Iwaoka, KI Priyadarsini
文献索引：Singh, Beena G.; Bag, Partha P.; Kumakura, Fumio; Iwaoka, Michio; Priyadarsini, K. Indira. Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 6 p. 703 - 708
Selenocystine (CysSeSeCys), a diselenide, exhibits glutathione peroxidase (GPx) activity, where it catalyses the reduction of hydroperoxides using a thiol co-factor. To understand the relative reactivity of the two substrates, enzyme kinetic parameters, ie, the turnover number (k cat) and the relative reactivity parameters toward thiol (φ G) and hydroperoxide (φ H), were determined by applying Dalziel kinetics for a bi-substrate model in the presence of ...
