Chemistry Letters

An Efficient Method for the p-Methoxybenzylation of Hydroxy Groups with 2-(4-Methoxybenzyloxy)-3-nitropyridine.

M Nakano, W Kikuchi, J Matsuo, T Mukaiyama

文献索引：Nakano, Masakazu; Kikuchi, Wataru; Matsuo, Jun-Ichi; Mukaiyama, Teruaki Chemistry Letters, 2001 ,  # 5  p. 424 - 425

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被引用次数: 12

摘要

2-(4-Methoxybenzyloxy)-3-nitropyridine (PMBONPy), easily prepared from 2-chloro-3- nitropyridine and p-methoxybenzyl (PMB) alcohol, reacts with various types of hydroxy groups in the presence of a catalytic amount of trimethylsilyl triflate (Me 3 SiOTf) to give the corresponding PMB ethers in high yields under mild conditions.