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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of optically active. beta.,. gamma.-epoxy alcohols and secondary allylic alcohols via diastereoselective addition of. alpha.-(trimethylsilyl)-. alpha.,. beta.- …

Y Takeda, T Matsumoto, F Sato

文献索引：Takeda, Yoshiyuki; Matsumoto, Takashi; Sato, Fumie Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4728 - 4731

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被引用次数: 43

摘要

" The reactions were carried out at-78-0'C (1-2 h) in ether.* Determined by HPLC analysis. cErythro isomers were assigned by spectroscopic methods and by comparison with the authentic materials. Isolated yields. e Purified by column chromatography on silica gel./The ratio was lowered to 2.8: 1 by using THF as solvent. gThe ratio was lowered to 2.6: l in THF.

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

(S,Z)-2-(2-ethoxyethoxy)oct-3-ene结构式

(S,Z)-2-(2-etho...

(2S,3S)-3-butyl-2-(trimethylsilyl)oxirane-2-carbaldehyde结构式

(2S,3S)-3-butyl...

~%

(S,Z)-2-(2-ethoxyethoxy)oct-3-ene结构式

(S,Z)-2-(2-etho...

(S)-1-((2R,3S)-3-butyl-2-(trimethylsilyl)oxiran-2-yl)ethanol结构式

(S)-1-((2R,3S)-...

~%

(S,Z)-2-(2-ethoxyethoxy)oct-3-ene结构式

(S,Z)-2-(2-etho...

(S,Z)-2-(2-ethoxyethoxy)oct-3-ene结构式

(S,Z)-2-(2-etho...

~92%

(S)-(Z)-3-octen-2-ol结构式

(S)-(Z)-3-octen-2-ol

(S)-1-((2R,3S)-3-butyl-2-(trimethylsilyl)oxiran-2-yl)ethanol结构式

(S)-1-((2R,3S)-...

~%

(S)-(Z)-3-octen-2-ol结构式

(S)-(Z)-3-octen-2-ol

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

(S)-(Z)-3-octen-2-ol结构式

(S)-(Z)-3-octen-2-ol

(2S,3S)-3-butyl-2-(trimethylsilyl)oxirane-2-carbaldehyde结构式

(2S,3S)-3-butyl...

~%

(S)-(Z)-3-octen-2-ol结构式

(S)-(Z)-3-octen-2-ol

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

(S)-1-((2R,3S)-3-butyl-2-(trimethylsilyl)oxiran-2-yl)ethanol结构式

(S)-1-((2R,3S)-...

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

((2R,3S)-3-butyl-2-((S)-1-(2-ethoxyethoxy)ethyl)oxiran-2-yl)trimethylsilane结构式

((2R,3S)-3-buty...

(2S,3S)-3-butyl-2-(trimethylsilyl)oxirane-2-carbaldehyde结构式

(2S,3S)-3-butyl...

~%

((2R,3S)-3-butyl-2-((S)-1-(2-ethoxyethoxy)ethyl)oxiran-2-yl)trimethylsilane结构式

((2R,3S)-3-buty...

(S)-1-((2R,3S)-3-butyl-2-(trimethylsilyl)oxiran-2-yl)ethanol结构式

(S)-1-((2R,3S)-...

~87%

(2S,3S,4S)-3-(trimethylsilyl)octane-2,4-diol结构式

(2S,3S,4S)-3-(t...

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

(2S,3S,4S)-3-(trimethylsilyl)octane-2,4-diol结构式

(2S,3S,4S)-3-(t...

(2S,3S)-3-butyl-2-(trimethylsilyl)oxirane-2-carbaldehyde结构式

(2S,3S)-3-butyl...

~%

(2S,3S,4S)-3-(trimethylsilyl)octane-2,4-diol结构式

(2S,3S,4S)-3-(t...

(Z)-(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilyl-hept-2-en-1-ol结构式

(Z)-(1S,4'R)-1-...

~%

(2S,3S)-3-butyl-2-(trimethylsilyl)oxirane-2-carbaldehyde结构式

(2S,3S)-3-butyl...