Abstract A series of derivatives of cinnamic amide (compounds 2a–2v) were synthesized and evaluated for antiproliferative activities against the human breast cancer cell line MCF-7- and EGFR-inhibitory activities. The structures of compounds 2b and 2i were determined by single-crystal X-ray diffraction analysis. Compounds 2f and 2j showed moderate EGFR inhibitory activity with IC 50 values of 5.16 and 7.37 μM, respectively. Docking simulation ...
