Synthesis and antiproliferative activity of pyridinylcarbonylpyrimidines against melanoma cell line

HM Ahn, JA Lee, H Kim, CH Oh, SH Lee…

文献索引：Ahn, Hyemi; Lee, Jun A.; Kim, Hwan; Oh, Chang-Hyun; Lee, So Ha; Sim, Taebo; Hah, Jung-Mi; Kim, Dong Jin; Yoo, Kyung Ho Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 4 p. 1209 - 1214

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摘要

Abstract The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib () as a reference compound. In our series, urea compound 1o having 4-chloro-3-trifluoromethyl moiety on ...