Synthesis of pressinoic acid by enzymatically catalyzed formation of peptide bonds

V Čeřovský

文献索引：Cerovsky, Vaclav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360

被引用次数: 6

摘要

Abstract Three fully enzymatic syntheses of the 1-6 vasopressin hexapeptide were investigated using papain, α-chymotrypsin and thermolysin. Best results were obtained with thermolysin in the 2+ 4 fragment condensation. The α-chymotrypsin-catalyzed 3+ 3 condensation is less advantageous and the 4+ 2 condensation with papain gave only low yield. Using the mentioned enzymes, further fragments of vasopressin molecule were ...