Organic synthesis with enzymes. 3. TBADH-catalyzed reduction of chloro ketones. Total synthesis of (+)-(S, S)-(cis-6-methyltetrahydropyran-2-yl) acetic acid: a civet …
E Keinan, KK Seth, R Lamed
文献索引：Keinan, Ehud; Seth, Kamal K.; Lamed, Raphael Journal of the American Chemical Society, 1986 , vol. 108, # 12 p. 3474 - 3480
Abstract: Highly enantioselective reduction of aliphatic chloro ketones catalyzed by Thermoanaerobium brockii alcohol dehydrogenase (TBADH) afforded the corresponding S chloro alcohols, which are new and useful chiral bifunctional building blocks. The synthetic potential of these compounds was illustrated by syntheses of several optically pure cyclic ethers. In particular,(S)-(+)-5-chloropentan-2-01 was used for the total synthesis of (+)-(S+ ...
