Journal of Heterocyclic Chemistry

Furopyridines. I. Synthesis of furo [2, 3??c] pyridine

S Shiotani, H Morita

文献索引：Shiotani, Shunsaku; Morita, Hiroyuki Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1207 - 1209

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被引用次数: 20

摘要

Abstract The parent framework of furo [2, 3-c] pyridine has been synthesized. 3-Furoic acid chloride (2) was reduced with bis (triphenylphosphine) copper (1) tetrahydroborate to afford 3-furaldehyde (3) which was condensed with malonic acid to give β-(3-furyl) acrylic acid (4). The acrylic acid 4 was converted to the acid azide (5), which in turn was cyclized to give furo [2, 3-c] pyridin-7 (6H)-one (6) by heating at 180 in diphenylmethane. The pyridone 6 was ...