Proton NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of" enkephalinase" inhibitors. …

MC Fournié-Zaluski, E Lucas-Soroca…

文献索引：Fournie-Zaluski; Lucas-Soroca; Devin; Roques Journal of medicinal chemistry, 1986 , vol. 29, # 5 p. 751 - 757

被引用次数: 37

摘要

[3-[[1 (RS)-(mercaptomethyl)-2-phenylethyl] amino]-3-oxopropanoic acid], two highly potent inhibitors of enkephalinase, a neutral endopeptidase involved in enkephalin metabolism, is reported. Due to a rapid isomerization process, derivatives of retro-thiorphan, which contains a 2-substituted malonyl moiety, cannot be separated by classical methods. However, a separation of the diastereoisomeric mixtures of these retro-thiorphan derivatives was ...