Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides

…, DM Sheehan, NK Christensen…

文献索引：Dellinger, Douglas J.; Sheehan, David M.; Christensen, Nanna K.; Lindberg, James G.; Caruthers, Marvin H. Journal of the American Chemical Society, 2003 , vol. 125, # 4 p. 940 - 950

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被引用次数: 51

摘要

Phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides were prepared via a solid-phase synthesis strategy. Under Reformatsky reaction conditions, novel esterified acetic acid phosphinodiamidites were synthesized and condensed with appropriately protected 5'-O-(4, 4'-dimethoxytrityl)-2'-deoxynucleosides to yield 3'-O-phosphinoamidite reactive monomers. These synthons when activated with tetrazole were used with an ...