Stereocontrolled total syntheses of isodomoic acids G and H via a unified strategy

SE Denmark, JHC Liu, JM Muhuhi

文献索引：Denmark, Scott E.; Liu, Jack Hung-Chang; Muhuhi, Joseck M. Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 201 - 215

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被引用次数: 17

摘要

Marine neuroexcitatory compounds isodomoic acids G and H were efficiently synthesized from a common intermediate using a silicon-based cross-coupling reaction. Dividing each target compound into the core fragment and the side-chain fragment enabled the synthesis to be convergent. The trans-2, 3-disubstituted pyrrolidine core fragment was accessed through a diastereoselective rhodium-catalyzed carbonylative silylcarbocyclization ...