Bioorganic & medicinal chemistry letters

Acid-catalyzed synthesis of 10-substituted triazolyl artemisinins and their growth inhibitory activity against various cancer cells

S Oh, WS Shin, J Ham, S Lee

文献索引：Oh, Sangtae; Shin, Woon-Seob; Ham, Jungyeob; Lee, Seokjoon Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4112 - 4115

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被引用次数: 22

摘要

A diastereomeric and regioisomeric library of 10-substituted triazolyl artemisinin compounds (6a–6h, 7a–7h, and 8a–8h) with a potent growth inhibitory activities against various cancer cell lines was established. These compounds were synthesized by a reaction with dihydroartemisinin (2) and various substituted triazoles (5a–5h) in methylene chloride using a BF3Et2O catalyst. Most of the compounds exhibited a strong potency in the ...