(+)-(2R, 5S)-4-[4-Cyano-3-(trifluoromethyl) phenyl]-2, 5-dimethyl-N-[6-(trifluoromethyl) pyridin-3-yl] piperazine-1-carboxamide (YM580) as an Orally Potent and …

I Kinoyama, N Taniguchi, A Toyoshima…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 2 p. 716 - 726

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被引用次数: 26

摘要

... Journal of Medicinal Chemistry. ... 2. Chemistry. As shown in Scheme 1, two general synthetic procedures were adopted to obtain the target urea derivatives. Our first approach involved the coupling of in situ intermediate ...