Identification and synthesis of impurities formed during sertindole preparation

IVS Kumar, GSR Anjaneyulu…

文献索引：Sunil Kumar; Anjaneyulu; Hima Bindu Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 29 - 33

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被引用次数: 4

摘要

Abstract Sertindole (1), an atypical anti-psychotic drug is used for the treatment of schizophrenia. During the laboratory optimization and later during its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation patterns in LC- MS. Most of the impurities were synthesized and their assigned constitutions confirmed by ...