Benzothieno [3, 2-b] indole derivatives as potent selective estrogen receptor modulators

Q Ji, J Gao, J Wang, C Yang, X Hui, X Yan, X Wu…

文献索引：Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893

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被引用次数: 15

摘要

A series of estrogen receptor ligands based on benzothieno [3, 2-b] indole were synthesized and their binding affinity for estrogen receptor subtypes (ERα and ERβ) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.