Journal of medicinal chemistry

3, 4-Dihydro-2 (1H)-quinazolinones

WE Coyne, JW Cusic

文献索引：Coyne,W.E.; Cusic,J.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213

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被引用次数: 45

摘要

D a Carried on directly to next step.* Required chromatography on silica. Compounds analyzed for C, H, and E; 8, 10, and 12, analyzed for N only. Uoiliiig point. 3-substituted quinazolinories were carried out using S a H in DlISO to give the desired products. The diamines required for the ring-closure step were prepared in several different ways (Chart 11). The most convenient method is reduction of the appropriately substituted 2- ...