Synthesis and Biological Evaluation of 5-Benzylidenepyrimidine-2, 4, 6 (1 H, 3 H, 5 H)-trione Derivatives for the Treatment of Obesity-Related Nonalcoholic Fatty Liver …

…, Y Ran, X Liang, L Huang, H Pei, J Chen…

文献索引：Ma, Liang; Xie, Caifeng; Ran, Yan; Liang, Xiaolin; Huang, Li; Pei, Heying; Chen, Jinying; Liu, Juan; Sang, Yun; Lai, Huijun; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9958 - 9972

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被引用次数: 9

摘要

Nonalcoholic fatty liver disease (NAFLD), one of chronic liver diseases, seems to be rising as the obesity epidemic continues. In this study, 54 novel (thio) barbituric acid derivatives have been synthesized and evaluated for pharmacological activity. 7h exhibited potent glucose-lowering effects on insulin-resistant HepG2 cells and regulated adiponectin and leptin expression in 3T3-L1 adipocytes. Oral administration of 7h at 25 mg kg–1 day–1 for ...