Organic letters

Oxidative Mannich Reaction of N-Carbobenzyloxy Amines with 1, 3-Dicarbonyl Compounds

J Matsuo, Y Tanaki, H Ishibashi

文献索引：Matsuo, Jun-Ichi; Tanaki, Yumi; Ishibashi, Hiroyuki Organic Letters, 2006 , vol. 8, # 19 p. 4371 - 4374

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被引用次数: 15

摘要

The Mannich reaction is a fundamental carbon−carbon bond-forming reaction in organic synthesis, 1 and a variety of nitrogen-containing pharmaceuticals and bioactive molecules such as β-amino acids and β-lactams are synthesized by this reaction. Recently, catalytic enantioselective Mannich reactions have been dramatically developed, and they offer a practically useful method for the preparation of optically active amino compounds. 2,3 However, inherent weak ...