Organic letters

Application of Ynamides in the Synthesis of 2-Amidoindoles

K Dooleweerdt, T Ruhland, T Skrydstrup

文献索引：Dooleweerdt, Karin; Ruhland, Thomas; Skrydstrup, Troels Organic Letters, 2009 , vol. 11, # 1 p. 221 - 224

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被引用次数: 54

摘要

A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o- iodoanilines is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.