Tetrahedron letters

Oxidation of thiol by 5-arylidene 1, 3-dimethylbarbituric acid and its application to synthesis of unsymmetrical disulfide

K Tanaka, X Chen, T Kimura, F Yoneda

文献索引：Tanaka, Kiyoshi; Chen, Xing; Kimura, Teiji; Yoneda, Fumio Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4173 - 4176

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被引用次数: 23

摘要

Abstract Oxidation of both aromatic and aliphatic thiols by 5-arylidene 1, 3-dimethylbarbituric acid was found to proceed readily to give disulfides in good yield with concomitant reduction of the oxidant to the dihydro compound. Thiol adduct of the dihydro compound was successfully applied to the synthesis of unsymmetrical disulfide under mild conditions in an excellent yield.