Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo [3, 4-b] pyridine and related heteroaromatic bicyclic …

…, M Anzini, L Mennuni, F Ferrari, G Caselli…

文献索引：Cappelli, Andrea; Nannicini, Chiara; Gallelli, Andrea; Giuliani, Germano; Valenti, Salvatore; Mohr, Galla Pericot; Anzini, Maurizio; Mennuni, Laura; Ferrari, Flora; Caselli, Gianfranco; Giordani, Antonio; Peris, Walter; Makovec, Francesco; Giorgi, Gianluca; Vomero, Salvatore Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2137 - 2146

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被引用次数: 32

摘要

Novel AT1 receptor antagonists bearing the pyrazolo [3, 4-b] pyridine bicyclic heteroaromatic system (or structurally related moieties) were designed and synthesized as the final step of a large program devoted to the development of new antihypertensive agents and to the understanding of the molecular basis of their pharmacodynamic and pharmacokinetic properties. The preliminary pharmacological characterization revealed ...