Phenytoin prodrugs III: Water??soluble prodrugs for oral and/or parenteral use

…, S Schuller, KB Sloan, VJ Stella

文献索引：Varia; Schuller; Sloan; Stella Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 8 p. 1068 - 1073

被引用次数: 120

摘要

Abstract Various bioreversible derivatives of phenytoin, a poorly water soluble and erratically absorbed drug after both oral and parenteral dosing, were synthesized. Initial evaluation of these expected prodrugs, ie, their aqueous solubility, cleavage in the presence of various animal tissues, and anticonvulsant activity in mice, confirmed that a number of the derivatives did indeed behave as prodrugs. The more promising prodrugs were the ...