Tetrahedron letters

The addition of amines to diisobutylaluminum-imine complexes. Preparation of NPS R-568 Hydrochloride

RM Barmore, SR Logan, BC VanWagenen

文献索引：Barmore, Robert M.; Logan, Sarah R.; Van Wagenen, Bradford C. Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3451 - 3454

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被引用次数: 14

摘要

A facile procedure for the preparation of secondary and tertiary amines from nitriles has been developed. The addition of amines to diisobutylaluminum-imine complexes derived by treating nitriles with DIBAL-H was found to proceed in moderate to good yields and was used to prepare NPS R-568 (1) hydrochloride, a potent calcium receptor agonist.