Synthesis and allergenic potential of a 15-hydroperoxyabietic acid-like model: trapping of radical intermediates

…, EG Arnau, AT Karlberg, JP Lepoittevin

文献索引：Mutterer; Gimenez Arnau; Karlberg; Lepoittevin Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 1028 - 1036

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被引用次数: 24

摘要

To better understand the skin sensitization mechanism of 15-hydroperoxyabietic acid-like compounds, 2-(1'-hydroperoxy-1'-methylethyl)-4a-methyl-3, 4, 4a, 5, 6, 7- hexahydronaphthalene 7 was synthesized. The allergenic activity of this compound was tested on mice using the local lymph node assay, and further evaluated on guinea pigs using the Freund's complete adjuvant test. Using these methods, hydroperoxide 7 was ...