Tetrahedron letters

CsOH-promoted epoxide ring-opening with phosphines: mild and efficient synthesis of monohydroxyphosphines

DL Fox, AA Robinson, JB Frank, RN Salvatore

文献索引：Fox, Daniel L.; Robinson, Ashlee A.; Frank, James B.; Salvatore, Ralph Nicholas Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7579 - 7582

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被引用次数: 14

摘要

A mild and convenient synthesis of monohydroxyphosphines has been achieved by epoxide ring-opening using primary or secondary phosphines in the presence of cesium hydroxide, 4 Å molecular sieves and DMF at room temperature. These reaction conditions were found to be highly regio-and stereoselective producing various monohydroxyphosphines exclusively in moderate to high yields.