Homogeneous nucleophilic radiofluorination and fluorination with phosphazene hydrofluorides

B Mathiessen, ATI Jensen…

文献索引：Mathiessen, Bente; Jensen, Andreas T. I.; Zhuravlev, Fedor Chemistry - A European Journal, 2011 , vol. 17, # 28 p. 7796 - 7805

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被引用次数: 17

摘要

Abstract A series of phosphazenium hydrofluorides, P 1 tBu⋅[18/19 F] HF, P 1 tOct⋅[18/19 F] HF, P 2 Et⋅[18/19 F] HF, and P 4 tBu⋅[18/19 F] HF, was synthesized. The radioactive phosphazenium [18 F] hydrofluorides were obtained by the one-step formation and trapping of gaseous [18 F] HF with the respective phosphazene bases. The [19 F] isotopomers were prepared from the corresponding phosphazene bases and Et 3 N⋅ 3HF. Under the design ...