Synlett

Facile and Selective Synthesis of Propargylic Amines and 1, 6-Diynes: One-Pot Three-Component Coupling Reactions of Alkynylsilanes, Aldehydes and Amines by a …

N Sakai, N Uchida, T Konakahara

文献索引：Sakai, Norio; Uchida, Naoki; Konakahara, Takeo Synlett, 2008 , # 10 p. 1515 - 1519

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被引用次数: 7

摘要

Abstract Described herein is a three-component coupling reaction of alkynylsilanes, aldehydes and amines by a cooperative catalytic system comprised of CuCl and Cu (OTf) 2, leading to the production of a variety of propargyl amine derivatives. This catalytic system was successfully applied to the practical preparation of 1, 6-diyne derivatives via twice- performed, domino-type coupling reactions.