The Journal of organic chemistry

Friedel-Crafts acylation and metalation strategies in the synthesis of calothrixins A and B

PH Bernardo, CLL Chai

文献索引：Bernardo, Paul H.; Chai, Christina L. L. Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 8906 - 8909

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被引用次数: 51

摘要

The novel natural products calothrixins A (1a) and B (1b) were first isolated and identified in 1999 by Rickards and co-workers. 1 The calothrixins have been shown to inhibit the growth of the chloroquine-resistant strain of the human malaria parasite, Plasmodium falciparum, as well as display potent cell-killing abilities against certain cancer cell lines. 1-3 Structurally the calothrixins have the novel indolophenanthridine skeleton, which combines the chemical motifs of a ...