. alpha. Anions of carboxylic acids. II. Formation and alkylation of. alpha.-metalated aliphatic acids

PE Pfeffer, LS Silbert, JM Chirinko Jr

文献索引：Pfeffer,P.E. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 451 - 458

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被引用次数: 123

摘要

The degree to which a anions of straight chain and a-branched chain carboxylic acids are formed by reaction with lithium diisopropylamide in solutions of tetrahydrofuran (THF) and tetrahydrofuran containing hexamethylphosphoramide (HMPA) was established by deuteration and carbonation. The determinations indicate the extent of the metalations of straight and a-branched chain acids to be unaffected by HMPA. Straight chain acids are ...