Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases

…, P Retailleau, BI Iorga, L Meijer, F Guéritte

文献索引：Nguyen, Thanh Binh; Lozach, Olivier; Surpateanu, Georgiana; Wang, Qian; Retailleau, Pascal; Iorga, Bogdan I.; Meijer, Laurent; Gueritte, Francoise Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2811 - 2819

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被引用次数: 18

摘要

The screening of the ICSN chemical library on various disease-relevant protein kinases led to the identification of natural flavonoidal alkaloids of unknown configuration as potent inhibitors of the CDK1 and CDK5 kinases. We thus developed an efficient and modular synthetic strategy for their preparation and that of analogues in order to determine the absolute configuration of the active natural flavonoidal alkaloids and to provide further ...