Preparation and study of new poly??8??hydroxyquinoline chelators for an anti??Alzheimer strategy

…, A Maraval, H Mazarguil, H Gornitzka…

文献索引：Deraeve, Celine; Boldron, Christophe; Maraval, Alexandrine; Mazarguil, Honore; Gornitzka, Heinz; Vendier, Laure; Pitie, Marguerite; Meunier, Bernard Chemistry - A European Journal, 2008 , vol. 14, # 2 p. 682 - 696

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被引用次数: 93

摘要

Abstract Fourteen different ligands have been synthesized with two covalently linked 8- hydroxyquinoline motifs that favor metal complexation. These bis-chelators include different bridges at the C2 positions and different substituents to modulate their physicochemical properties. They can form metal complexes in a ratio of one ligand per metal ion with Cu II and Zn II, two metal ions involved in the formation of amyloid aggregates of the toxic Aβ- ...