Bioavailability of Echinacea constituents: Caco-2 monolayers and pharmacokinetics of the alkylamides and caffeic acid conjugates
…, K Penman, N Matovic, K Bone, J De Voss, R Lehmann
文献索引：Matthias, Anita; Penman, Kerry G.; Matovic, Nick J.; Bone, Kerry M.; De Voss, James J.; Lehmann, Reg P. Molecules, 2005 , vol. 10, # 10 p. 1242 - 1251
Abstract: Many studies have been done over the years to assess the effectiveness of Echinacea as an immunomodulator. We have assessed the potential bioavailability of alkylamides and caffeic acid conjugates using Caco-2 monolayers and compared it to their actual bioavailability in a Phase I clinical trial. The caffeic acid conjugates permeated poorly through the Caco-2 monolayers. Alkylamides were found to diffuse rapidly through Caco-2 ...
