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Structure-activity relationships of a series of pyrrolo [3, 2-d] pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

…, N Han, R Hurt, T Jenkins, J Kincaid, L Liu…

文献索引:Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312

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被引用次数: 129

摘要

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo [3, 2-d] pyrimidine derivatives was prepared and evaluated for their ...

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