Linker-modified triamine-linked acridine dimers: Synthesis and cytotoxicity properties in vitro and in vivo

…, YJ Lee, SC Hsu, HO Chang, WK Yin, LS Chang…

文献索引：Wang, Shan-Shue; Lee, Yi-Jen; Hsu, Shih-Chung; Chang, Hsueh-O; Yin, Wei-Kung; Chang, Lien-Shange; Chou, Shan-Yen Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 735 - 748

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被引用次数: 13

摘要

The preparation and cytotoxicity properties of a series of Nε-substituted triamine-linked acridine dimers are described. Most acridine dimer derivatives reveal highly potent in vitro cytotoxicity properties and DNA binding activity. Several acridine dimers were selected to study their action in vivo. These acridine dimers have demonstrated a narrow safe margin, as has adriamycin, but higher maximum tolerate dose (MTD) in comparison with that of ...