Identification and full characterization of a new metabolite of metoclopramide

…, M De Amici, C De Micheli, P Rossato

文献索引：Maurich, V.; Amici, M. De; Micheli, C. De; Rossato, P. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 10 p. 757 - 762

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被引用次数: 8

摘要

The metabolism of metoclopramide 1 has been re investigated by HPLC coupled with mass spectrometry. The urine of healthy volunteers showed the presence of a new metabolite 2 derived from the enzymatic oxidation of the primary aromatic amino group of 1 to the hydroxylamino moiety. The structure of the new metabolite was ascertained by its fragmentation pattern in the mass spectrometer and unambiguously secured by an ...