Organic letters

Benzyl protection of phenols under neutral conditions: palladium-catalyzed benzylations of phenols

R Kuwano, H Kusano

文献索引：Kuwano, Ryoichi; Kusano, Hiroki Organic Letters, 2008 , vol. 10, # 10 p. 1979 - 1982

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被引用次数: 52

摘要

Benzyl protection of phenols under neutral conditions was achieved by using a Pd (η3- C3H5) Cp–DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers.