Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

…, PD Murray, LM O'Brien, PS Weisshaar, BL Ems

文献索引：Ares, Jeffrey J.; Outt, Pamela E.; Randall, Jared L.; Johnston, Jeffrey N.; Murray, Peter D.; O'Brien, Linda M.; Weisshaar, Pamela S.; Ems, Beth L. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 8 p. 995 - 998

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被引用次数: 39

摘要

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2–C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2-to the 3-position.