The synthesis, anti-inflammatory, and anti-microbial activity evaluation of new series of 4-(3-arylureido) phenyl-1, 4-dihydropyridine urea derivatives

RH Tale, AH Rodge, GD Hatnapure, AP Keche…

文献索引：Tale, Rajesh H.; Rodge, Atish H.; Hatnapure, Girish D.; Keche, Ashish P.; Patil, Kalpana M.; Pawar, Rajendra P. Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1450 - 1455

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被引用次数: 2

摘要

Abstract A new series of 4-(3-arylureido) phenyl-1, 4-dihydropyridine urea derivatives were synthesized using simple three component condensation, reduction, and nucleophilic addition sequence in moderate to good yields. All the synthesized compounds 6a–j were evaluated for their anti-inflammatory [against the pro-inflammatory cytokines (tumor necrosis factor-alpha, TNF-α and interleukin-6, IL-6)] and anti-microbial activity (anti-bacterial and ...