Antioxydant activity of β-carboline derivatives in the LDL oxidation model

F Hadjaz, S Besret, F Martin-Nizard, S Yous…

文献索引：Hadjaz, Fariza; Besret, Soizic; Martin-Nizard, Francoise; Yous, Said; Dilly, Sebastien; Lebegue, Nicolas; Chavatte, Philippe; Duriez, Patrick; Berthelot, Pascal; Carato, Pascal European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2575 - 2585

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被引用次数: 7

摘要

Abstract A series of β-carboline compounds were synthesized, starting from compound GWC22, their antioxidant activity was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO 4 or 2, 2′-azobis (2- amidinopropane) dihydrochloride (AAPH). The protective actions of these compounds against the cytotoxicity were evaluated with lactate dehydrogenase (LDH) activity in ...