Design, synthesis and biological activities of Nilotinib derivates as antitumor agents

X Pan, F Wang, Y Zhang, H Gao, Z Hu, S Wang…

文献索引：Pan, Xiaoyan; Wang, Fang; Zhang, Yanmin; Gao, Hongping; Hu, Zhigang; Wang, Sicen; Zhang, Jie Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2527 - 2534

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被引用次数: 7

摘要

A novel class of Nilotinib derivatives, B1–B20, were synthesized in high yields using various substituted anilines. All the title compounds were evaluated for their inhibitory activities against Bcr–Abl and antiproliferative effects on human leukemia cell (K562). The pharmacological results indicated that some compounds exhibited promising anticancer activity. In particular, compound B14 containing tertiary amine side chain exhibited Bcr– ...